Gong-Li Tang's Research Group State Key Laboratory of Bio-organic and Natural Products Chemistry,
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Publications from Independent Work (SIOC):

(2021 - present)

96. Wen, W. -H.; Zhang, Y.; Zhang, Y.-Y.; Yu Q, Jiang, C.-C.; Tang, M.-C.; Pu, J.-Y.; Wu, L.; Zhao, Y.-L.; Shi, T.*; Zhou, J.*; Tang, G.-L.* (2021) Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. Nat. Commun. 12, 7085. 

95.Zhang, W.-H., Wang, F.; Wang, Y.-L.; You, S.*; Pan, H.-X.*; Tang, G.-L.* (2021) Identification and Characterization of Enzymes Catalyzing Early Steps in Miharamycin and Amipurimycin Biosynthesis. Org. Lett. 23, 8761-8765.

94. Pei, Z.-F.†; Yang, M.-J.†; Zhang, K.; Jian, X.-H.; Tang, G.-L.* (2021) Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs. Cell Chem. Biol. PMID: 34474009.

93. Nie, Q.-Y.; Ji, Z.-Y.; Hu, Y.; Tang, G.-L.* (2021) Characterization of Highly Reductive Modification of Tetracycline D-Ring Reveals Enzymatic Conversion of Enone to Alkane. ACS Catalysis 11, 8399-8406.

92. Hu, Y.; Zhou, Q.; Zhang, Z.; Pan, H.-X.; Ilina, Y.; Metsä-Ketelä, M.; Igarashi, Y.; Tang, G.-L.* (2021) Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis. Chin. J. Chem., 39, 3329-3333. 

91. Zhou, Q.†; Peng, S.-Y.†; Zhang, K.; Luo, G.-C.; Han. L.; He, Q.-L.*; Tang, G.-L. * (2021) A Flavin-Dependent Monooxygenase Mediates Divergent Oxidation of Rifamycin. Org. Lett. 23, 2342-2346.


90. Zheng, X.-F.; Liu, X.-Q.; Peng, S.-Y.; Zhou Q.*; Xu. B. *; Yuan, H. *; Tang, G.-L. (2020)   Characterization of the Rifamycin-Degrading Monooxygenase From Rifamycin Producers Implicating Its Involvement in Saliniketal Biosynthesis. Front. Microbiol. 11, 971.

89. Yin, Y.; Shen, Y.; Meng, S.; Zhang, M.; Pan, H.-X.; Tang, G.-L. * (2020) Characterization of a membrane-bound O-acetyltransferase involved in trioxacarcin biosynthesis offers insights into its catalytic mechanism. Chin. J. Chem. 38, 1607-1611.

88. Wang, F.; Zhang, W.-H.; Zhao, J.; Kang, W.-J.; Wang, S.; Yu. B.; Pan, H.-X.*; Tang, G.-L.*(2020) Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS-PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. J. Am. Chem. Soc. 142, 5996-6000.

87. Hu, Y.†; Zhang, Z.†; Yin, Y.; Tang, G.-L.*(2020) Directed biosynthesis of iso-aclacinomycins with improved anticancer activity. Org. Lett. 22, 150-154.


86. Ji, Z.-Y.†; Nie, Q.-Y†.; Yin, Y.; Zhang, M.; Pan, H.-X.; Hou, X.-F.*; Tang, G.-L.*(2019) Activation and Characterization of a Cryptic Gene Cluster Reveal Two Series of Aromatic Polyketides Biosynthesized by Divergent Tailoring Pathways. Angew. Chem. Int. Ed. 58, 18046-18054.

85. Jin, W.-B.; Wu, S.; Xu, Y.-F.; Yuan, H.*; Tang, G.-L.* (2019) Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions. Nat. Prod. Rep. 37, 17-28.

84. Zhou, Q.;  Luo, G.-C.;  Zhang, H.*; Tang, G.-L.* (2019) Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway in Micromonospora sp. Strain TP-A0468. Appl. Environ. Microbiol. 85, e02597-18.

83. Shen, Y.;  Nie, Q.-Y.;  Yin, Y.;  Pan, H.-X.;  Xu, B.*; Tang, G.-L.*(2019) Production of a trioxacarcin analog by introducing a C-3 dehydratase into deoxysugar biosynthesis. Acta. Biochim. Biophys. Sin. (Shanghai) 51, 539-541.

82. Wang, S.; Zhang, Q.; Zhao, Y.; Sun, J.; Kang, W.; Wang, F.; Pan, H.; Tang, G.; Yu, B.* (2019) The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter. Angew. Chem. Int. Ed. 58, 10558-10562.

81. Pan, H.-X.;  Chen, Z.;  Zeng, T.;  Jin, W.-B.;  Geng, Y.;  Lin, G. M.;  Zhao, J.;  Li, W.-T.;  Xiong, Z.;  Huang, S.-X.;  Zhai, X.;  Liu, H.-W.*; Tang, G.-L.* (2019) Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. Org. Lett. 21, 1374-1378.

80. Kang, W.-J.†; Pan, H.-X.†; Wang, S.; Yu, B.;  Hua, H.*; Tang, G- L.* (2019) Identification of the Amipurimycin Gene Cluster Yields Insight into the Biosynthesis of C9 Sugar Nucleoside Antibiotics. Org. Lett. 21, 3148-3152.

79. Dong, L.; Shen, Y.; Hou, X.-F.; Li, W.-J.*; Tang, G.-L.* (2019) Discovery of Druggability-Improved Analogues by Investigation of the LL-D49194alpha1 Biosynthetic Pathway. Org. Lett. 21, 2322-2325.

78. Zhou, Q.; Luo, G.-C.; Zhang, H.-Z.*; Tang, G.-L.* (2019) 34a-Hydroxylation in Rifamycin Biosynthesis Catalyzed by Cytochrome P450 Encoded by rif-orf13. Chin. J. Org. Chem. 39, 1169-1174.


77. Wang, X.;  Wu, S.;  Jin, W.;  Xu, B.*;  Tang, G.*; Yuan, H.* (2018) Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin. Acta. Biochimica. Et Biophysica. Sinica. , 50, 516-518.

76. Pei, Z.-F.†; Yang, M.-J.†; Li ,L.†.; Jian, X.-H.; Yin, Y.; Li, D.; Pan, H.-X.; Lu, Y.; Jiang, W*.; Tang, G.-L.* (2018) Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system. Org. Biomol. Chem. 16, 9373-9376.

75. Wang, S.; Sun, J.; Zhang, Q.; Cao, X.; Zhao, Y.; Tang, G.; Yu, B.* (2018) Amipurimycin: Total Synthesis of the Proposed Structures and Diastereoisomers. Angew. Chem. Int. Ed. 57, 2884-2888.

74. Chen, X.-Y. †; Yin, Y. †; Xi, J.; Yuan, Y.; Li, Y.; Li, Q.; Wang, R.-X.; Yao, Z.*; Tang, G.-L.* (2018) 11‐Aza‐artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6). Chin. J. Chem. 36, 1197-1201.

73. Hou, X.-F.†; Song, Y.-J.†; Zhang, M.; Lan, W.; Meng, S.; Wang, C.; Pan, H.-X.; Cao, C.*; Tang, G.-L.* (2018) Enzymology of Anthraquinone-γ-Pyrone Ring Formation in Complex Aromatic Polyketide Biosynthesis. Angew. Chem. Int. Ed. 57,13475-13479.

72. Zhang, Y.†; Wen, W.-H.†; Pu, J.-Y.; Tang, M.-C.; Zhang, L.; Peng, C.; Xu, Y.; Tang, G.-L.* (2018) Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. Proc. Natl. Acad. Sci. USA. 115,11232-11237.

71. 金文兵; 袁华; 唐功利* (2018) 天然产物中环丙烷官能团的构筑策略. 有机化学 38, 2324-2334.

70. Meng, S.; Tang, G.-L.*; Pan, H.-X.* (2018) Enzymatic formation of oxygen‐containing heterocycles in natural product biosynthesis. ChemBioChem 19, 2002-2022.

69. Jin, W.-B.†; Wu, S.†; Jian, X.-H.; Yuan, H.*; Tang, G.-L.* (2018) A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. Nat. Commun. 9:2771.


68. Qi, F.†; Lei, C.†; Li, F.; Zhang, X.; Wang, J.; Zhang, W.; Fan, Z.; Li, W.; Tang, G.-L.; Xiao, Y.*; Zhao, G.; Li, S.* (2018) Deciphering the late steps of rifamycin biosynthesis. Nat. Commun. 9:2342.

67. Wang, X.; Wu, S.; Jin, W.-B.; Xu, B.*; Tang, G.-L.*, Yuan, H.* (2018) Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin. Acta Biochim. Biophys. Sin. 50, 516-518.

66. Meng, S.; Han, W.; Zhao, J.; Jian, X.; Pan, H.-X.*; Tang, G.-L.* (2018) A Six‐Oxidase Cascade for Tandem C−H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis. Angew. Chem. Int. Ed. 57, 719-723.




65.  Yuan, H.†; Zhang, J.†; Cai, Y.; Wu, S.; Yang, K.; Chan, S.; Huang, W.; Jin, W.-B.; Li, Y.; Yin, Y.; Igarashi, Y.; Yuan, S.*; Zhou, J.*; Tang, G.-L.* (2017) GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nat. Commun. 8:1485.



64. He, N.†; Wu, P.†; Lei, Y.; Xu, B.; Zhu, X.; Xu, G.; Gao, Y.; Qi, J.; Deng, Z.; Tang, G.-L.; Chen, W.*; Xiao, Y.* (2017) Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics. Chem. Sci. 8, 444-451.

63. Song, L.-Q.†; Zhang, Y.-Y.†; Pu, J.-Y.†; Tang, M.-C.; Peng, C.; Tang, G.-L.* (2017) Catalysis of extracellular deamination by a FAD-linked oxidoreductase after prodrug maturation in the biosynthesis of saframycin A. Angew. Chem. Int. Ed. 56, 9116-9120.

62.  Wu, S.†; Jian, X.-H.†; Yuan, H.†; Jin, W.-B.; Yin, Y.; Wang, L.-Y.; Zhao, J.; Tang, G.-L.* (2017) Unified biosynthetic origin of the benzodipyrrole subunits in CC-1065. ACS Chem. Biol. 12, 1603-1610.

61.  Zhang, Z.; Pan, H.-X.; Tang, G.-L.* (2017) New insights into bacterial type II polyketide biosynthesis. F1000Res. 6, 172.

60.  Zhang, Z.†; Gong, Y.-K.†; Zhou, Q.; Hu, Y.; Ma, H.-M.; Chen, Y.-S.; Igarashi, Y.; Pan, L.*; Tang, G.-L.* (2017) Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. Proc. Natl. Acad. Sci. USA. 114, 1554–1559.

59.  亢文佳,吴晟,华会明*, 潘海学,唐功利* (2016) 基于基因组挖掘的一个新的吡嗪酮类天然产物的发现. 有机化学36, 1696-1699。

58.  Tang, G.-L.*; Tang, M.-C.; Song, L.-Q.; Zhang, Y. (2016) Biosynthesis of tetrahydroisoquinoline antibiotics. Curr. Top. Med. Chem. 16, 1717-1726.

57.  Wu, L.-F.; Meng, S.; Tang, G.-L.* (2016) Ferrous iron and α-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products. Biochim. Biophy. Acta. 1864, 453-470.

56.  潘海学,袁华,蹇晓红,唐功利* (2015) 天然产物生物合成与抗肿瘤药物合成生物学研究。中国科学:生命科学45, 1027-1039。

55.  Yang, K.†; Qi, L.-H.†; Zhang, M.; Hou, X.-F.; Pan, H.-X.; Tang, G.-L.; Wang, W.*; Yuan, H.* (2015) The SARP family regulator txn9 and two-component response regulator txn11 are key activators for trioxacarcin biosynthesis in Streptomyces bottropensis.Curr. Microbiol. 71, 458-464.

54.  Zhang, M.†; Hou, X.-F.†; Qi, L.-H.; Yin, Y.; Li, Q.; Pan, H.-X.; Chen, X.-Y.; Tang, G.-L.* (2015) Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase. Chem. Sci. 6, 3440-3447. (Highlighted in "Hot off the press" Nat. Prod. Rep. 2015, 32, 1165-1169)


53.  Qiu, H.-B.; Chen, X.-Y.; Li, Q.; Qian, W.-J.; Yu, S.-M.; Tang, G.-L.; Yao, Z.-J.* (2014) Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions. Tetrahedron Lett., 55, 6055-6059.

52.  He, H.-Y.; Yuan, H.; Tang, M.-C.; Tang, G.-L.* (2014) An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis. Angew. Chem. Int. Ed. 53, 11315-11319

51.  漆丽华,张媚,潘海学,陈晓东*,唐功利* (2014) 基于生物合成途径改造的一个三欣卡辛类似物的发现。有机化学34, 1376-1381

50.  He, H.-Y.; Tang, M.-C.; Zhang, F.; Tang, G.-L.* (2014) Cis-Double bond formation by thioesterase and transfer by ketosynthase in FR901464 biosynthesis. J. Am. Chem. Soc. 136, 4488-4491. (Highlighted in "Hot off the press" Nat. Prod. Rep. 2014, 31, 706-710; Chin. J. Org. Chem. 2014, 34, 1034-1035)

49.  Wu, L.-F.†; He, H.-Y.†; Pan, H.-X.; Han, L.; Wang, R.; Tang, G.-L.* (2014) Characterization of QmnD3/QmnD4 for double bond formation in quartromicin biosynthesis. Org. Lett. 16, 1578-1581.

48.  Wang, J.-B.; Zhang, F.; Pu, J.-Y.; Zhao, J.; Zhao, Q.-F.; Tang, G.-L.* (2014) Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. Biotechnol. Lett. 36, 813-819.

47.  Pan, H.-X.; Chen, Z.-Z.; Shao, L.; Li, J.-A.; Chen, J.-S.; Zhu, C.-B.; Tang, G.-L.*, Chen, D.-J.* (2013) Production of ramoplanin analogues by genetic engineering of Actinoplanes sp. Biotechnol. Lett. 35, 1685-1692.

46.  Pu, J.-Y.†; Peng, C.†; Tang, M.-C.; Zhang, Y.; Guo, J.-P.; Song, L.-Q.; Hua, Q.; Tang, G.-L.* (2013) Naphthyridinomycin biosynthesis revealing the use of leader peptide to guide nonribosomal peptide assembly. Org. Lett. 15, 3674-3677.
(Highlighted in "Hot off the press" Nat. Prod. Rep. 2013, 30, 1272-1276)

45.  潘海学,唐功利* (2013) 非核糖体肽合成酶催化的非常规装配模式(邀请综述)。微生物学报,40, 1783-1795

44.  Li, J.-E.; Guo, Z.-Y.; Huang, W.; Meng, X.-X.; Ai, G.-M.; Tang, G.-L.*, Chen, Y.-H.* (2013) Mining of a of a streptothricin gene cluster from the Streptomyces sp. TP-A0356 genome via heterologous expression. Sci. China Life Sci. 56, 619-627.

43.  Wei, Y.; Wang, T.; Liu, C.; Zhang, Q.; Wang, L.; Tang, G.; Kang, J.* (2013) Drug target identification using affinity-core shell magnetic nonoparticles and mass spectrometry. Chin. J. Chem. 31, 715-720.

42.  李慧,周强,唐玉敏,赵圣印*,唐功利* (2013) 越野他汀生物合成介导的海洋小单孢菌中一个新天然产物的发现。有机化学33, 1326-1332

41.  Liu, X.; Biswas, S.; Tang, G.-L.; Cheng, Y.-Q.* (2013) Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663. J. Antibiot. (Tokyo) (doi: 10.1038/ja.2013.38).
40.  Ma, H.-M.†; Zhou, Q.†; Tang, Y.-M.†; Zhang, Z.†; Chen, Y.-S.; He, H.-Y.; Pan, H.-X.; Tang, M.-C.; Gao, J.-F.; Zhao, S.-Y.; Igarashi, Y.; Tang, G.-L.* (2013) Unconventional origin and hybrid system for construction of pyrrolopyrrole moiety in kosinostatin biosynthesis. Chem. Biol. 20, 796-805.

39.  Liu, X.; Biswas, S.; Berg, M. G.; Antapli, C. M.; Xie, F.; Wang, Q.; Tang, M.-C.; Tang, G.-L.; Zhang, L.; Dreyfuss, G.; Cheng, Y.-Q.* (2013) Genomics-guided discovery of Thailanstatins A, B, and C as pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J. Nat. Prod. 76, 685-693.

38.  Arnison, P. G.; Bibb, M. J.; Bierbaum, G.; Bowers, A. A.; Bugni, T. S.; Bulaj, G.; Camarero, J. A.; Campopiano, D. J.; Challis, G. L.; Clardy, J.; Cotter, P. D.; Craik, D. J.; Dawson, M.; Dittmann, E.; Donadio, S.; Dorrestein, P. C.; Entian, K. D.; Fischbach, M. A.; Garavelli, J. S.; Göransson, U.; Gruber, C. W.; Haft, D. H.; Hemscheidt, T. K.; Hertweck, C.; Hill, C.; Horswill, A. R.; Jaspars, M.; Kelly, W. L.; Klinman, J. P.; Kuipers, O. P.;Link, A. J.; Liu, W.; Marahiel, M. A.; Mitchell, D. A.; Moll, G. N.; Moore, B. S.; Müller, R.; Nair, S. K.; Nes, I. F.; Norris, G. E.; Olivera, B. M.; Onaka, H.; Patchett, M. L.; Piel, J.; Reaney, M. J.; Rebuffat, S.; Ross, R. P.; Sahl, H. G.; Schmidt, E. W.; Selsted, M. E.; Severinov, K.; Shen, B.; Sivonen, K.; Smith, L.; Stein, T.; Süssmuth, R. D.; Tagg, J. R.; Tang, G.-L.; Truman, A. W.; Vederas, J. C.; Walsh, C. T.; Walton, J. D.; Wenzel, S. C.; Willey, J. M.; van der Donk, W. A.* (2013) Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat. Prod. Rep. 30, 108-160.

37.  Tang, M.-C.; He, H.-Y.; Zhang, F.; Tang, G.-L.* (2013) Baeyer-Villiger oxidation of acyl carrier protein-tethered thioester to acyl carrier protein-linked thiocarbonate catalyzed by a monooxygenase domain in FR901464 biosynthesis. ACS Catal. 3, 444-447.

36.  Pan, H.-X.; Li, J.-A.; Shao, L.; Zhu, C.-B.; Chen, J.-S.; Tang, G.-L.*, Chen, D.-J.* (2013) Genetic manipulation revealing an unusual N-terminal region in a stand-alone non-ribosomal peptide synthetase involved in the biosynthesis of ramoplanins. Biotechnol. Lett. 35, 107-114.


35.  He, H.-Y.†; Pan, H.-X.†; Wu, L.-F.; Zhang, B.-B.; Chai, H.-B.; Liu, W.; Tang, G.-L.* (2012) Quartromicin biosynthesis: two alternative polyketide chains produced by one polyketide synthase assembly line. Chem. Biol. 19, 1313-1323.

34.  Xu, H.†; Huang, W.†; He, Q.-L.; Zhao, Z.-X.; Zhang, F.; Wang, R.; Kang, J.; Tang, G.-L.* (2012) Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis. Angew. Chem. Int. Ed. 51, 10532-10536. (Highlighted in Nat. Chem. Biol. 2012, 8, 873)

33.  Chen, Y.-L.; Zhao, J.; Liu, W.; Gao, J.-F.; Tao, L.-M.; Pan, H.-X.*; Tang, G.-L.* (2012) Identification of phoslactomycin biosynthetic gene clusters from Streptomyces platensis SAM-0654 and characterization of PnR1 and PnR2 as positive transcriptional regulators. Gene 509, 195-200.

32.  唐满成,唐功利* (2012) 抗肿瘤活性四氢异喹啉抗生素的生物合成研究进展(邀请综述)。有机化学32, 1568-1576

31.  Huang, W.†; Xu, H.†; Li, Y.†; Zhang, F.; Chen, X.-Y.; He, Q.-L.; Igarashi, Y.; Tang, G.-L.* (2012) Characterization of yatakemycin gene cluster revealing a radical S-adenosylmethionine dependent methyltransferase and highlighting spirocyclopropane biosynthesis. J. Am. Chem. Soc. 134, 8831-8840. (Highlighted in "Hot off the press" Nat. Prod. Rep. 2012, 29, 829-833)

30.  Peng, C.†; Pu, J.-Y.†; Song, L.-Q.†; Jian, X.-H.†; Tang, M.-C.; Tang, G.-L.* (2012) Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line. Proc. Natl. Acad. Sci. U.S.A. 109, 8540-8545.

29.  Jian, X.-H.; Pan, H.-X.; Ning, T.-T.; Shi, Y.-Y.; Chen, Y.-S.; Li, Y.; Zeng, X.-W.; Xu, J.; Tang, G.-L.* (2012) Analysis of YM-216391 biosynthetic gene cluster and improvement of the cyclopeptide production in a heterologous host. ACS Chem. Biol. 7, 646-651.

28.  Tang, M.-C.; Fu, C.-Y.; Tang, G.-L.* (2012) Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis. J. Biol. Chem. 287, 5112-5121.

27.  Peng, C.; Tang, Y.-M.; Li, L.; Ding, W.; Deng, W.; Pu, J.-Y.; Liu, W.; Tang, G.-L.* (2012) In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O. Sci. China Chem. 55, 90-97.

26.  黄伟,王健博,唐功利* (2011) 天然产物类药物的合成生物学研究(邀请综述)。生命科学23,891-899

25.  Zhang, F.; He, H.-Y.; Tang, M.-C.; Zhou, Q.; Tang, G.-L.* (2011) Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units. J. Am. Chem. Soc. 133, 2452-2462. (Highlighted as “of outstanding interest” in Curr. Opin. Chem . Biol. 2012, 16, 117-123.)

24.  Wang, J.-B.; Pan, H.-X.; Tang, G.-L.* (2011) Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg. Med. Chem. Lett. 21, 3320-3323.

(Before 2010)
23.  Fu, C.-Y.; Tang, M.-C.; Peng, C.; Li, L.; He, Y.-L.; Liu, W. Tang, G.-L.* (2009) Biosynthesis of 3-hydroxy-5-methyl-O-methyltyrosine in the saframycin/ safracin biosynthetic pathway. J. Microbiol. Biotechnol. 19, 439-446.

22.  唐功利* (2009) 天然产物的代谢工程与菌种改良(邀请综述)。上海化工, 34, 16-22.

21.  He, Q.-L.; Jia, X.-Y.; Tang, M.-C.; Tian, Z.-H.; Tang, G.-L.*; Liu, W.* (2009) Dissection of two acyl transfer reactions centered on acyl-S-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin. ChemBioChem 10,813-819.

20.  Yu, Y.; Duan, L.; Zhang, Q.; Liao, R.; Ding, Y.; Pan, H.; Wendt-Pienkowski, E.; Tang, G.; Shen, B.; Liu, W.* (2009) Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem. Biol. 10, 855-864.

19.  Li, L.; Deng, W.; Song, J.; Ding, W.; Zhao, Q.-F.; Peng, C.; Song, W.-W.; Tang, G.-L.*; Liu, W.*(2008)Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. J. Bacteriol. 190, 251-263.

18.  He, Q.-L.; Jiang, H.; Zhang, F.; Chen, H-B.; Tang, G.-L.* (2008) Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning. Bioorg. Med. Chem. Lett. 18, 3995-3998.

17.  Zhao Q, He Q, Ding W, Tang M, Kang Q, Yu Y, Deng W, Zhang Q, Fang J, Tang G, Liu W*. (2008) Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chem. Biol. 15, 693-705.

16.  Fang J, Zhang Y, Huang L, Jia X, Zhang Q, Zhang X, Tang G, Liu W*. (2008) Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics. J. Bacteriol. 190, 6014-25.

15.  Jia, X.-Y.; Tian, Z.-H.; Shao, L.; Qu, X.-D.; Zhao, Q.-F.; Tang, J.; Tang, G.-L.*; Liu, W.* (2006) Genetic characterization of the chlorothricin biosynthetic gene cluster as a model for spirotetronate antibiotic biosynthesis. Chem. Biol. 13, 575-585.

14.  Shao, L.; Qu, X.-D.; Jia, X.-Y.; Zhao, Q.-F.; Tian, Z.-H.; Wang, M.; Tang, G.-L.*; Liu, W.* (2006) Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochem. Biophy. Res. Comm. 345, 133-139.

13.  刘文,唐功利 (2005) 以生物合成为基础的代谢工程和组合生物合成(专题综述) 中国生物工程杂志 25,1-5


Publications from Postdoctoral Work:
12.  Huang, Y.; Huang, S.-X.; Ju, J.; Tang, G.; Liu, T.; Shen, B. (2011) Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis. Org. Lett. 13, 498-501.

11.  Tang, G.-L. ; Cheng, Y.-Q.; Shen, B. (2007) Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. J. Biol. Chem. 282, 20273-20282.

10.  Tang, G.-L. ; Cheng, Y.-Q.; Shen, B. (2006) Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. J. Nat. Prod. 69, 387-393.

9.   Tang, G.-L. *; Cheng, Y.-Q. *; Shen, B. (2004) Leinamycin Biosynthesis Revealing Unprecedented Architectural Complexity for a Hybrid Polyketide Synthase and Nonribosomal Peptide Synthetase. (*These authors contribute equally to this work) Chem.& Biol. 11, 33-45.

8.   Cheng, Y.-Q.*; Tang, G.-L.*; Shen, B. (2003) Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. (*These authors contribute equally to this work) Proc. Natl. Acad. Sci. U.S.A. 100, 3149-3154 [Featured in Proc. Natl. Acad. Sci. USA 2003, 100, 3010-3012].

7.   Cheng, Y.-Q.; Tang, G.-L.; Shen, B. (2002) Identification and localization of the antitumor macrolactam leinamycin biosynthesis gene cluster from streptomyces atroolivaceus S-140. J Bacteriol. 184, 7013-7024.


Publications from Graduate Work:
6.   Tang, G.-L.; Wang, Y.-F.; Bao, J.-S.; Chen, H.-B. (2001) Two-cistron system overexpression of chloroplast glyceraldehyde-3-phosphate dehydrogenase subunit B and B-derivatives from spinach in E. coli. Protein Expression Purif. 22, 31-37.

5.   唐功利,杨春松,鲍建绍,王燕芳,陈海宝,施定基,刘凤龙 (2001) 丙糖磷酸异构酶、果糖-1,6-二磷酸醛缩酶及果糖-1,6-二磷酸酶的共表达. 生物化学与生物物理学报. 33, 131-136

4.   Tang, G.-L.; Wang, Y.-F.; Bao, J.-S.; Chen, H.-B. (2000) Overexpression in E. coli and characterization of the chloroplast fructose-1,6-bisphosphatase from wheat. Protein Expression Purif. 19, 411-418.

3.   唐功利,陈海宝(2000) 代谢工程研究进展(综述),有机化学. 20, 634-640。

2.   唐功利,麻锦彪,吴厚铭,陈海宝 (2000)生物活性小分子与靶点相互作用研究中的新方法和新技术(评述),科学通报. 45, 1345-1357。

1.   Tang, G.-L.; Wang, Y.-F.; Bao, J.-S.; Chen, H.-B. (1999) Overexpression in E. coli and    characterization of the chloroplast triosephosphate isomerase from spinach. Protein  Expression Purif. 16, 432-439.

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